BAK1 and BID

Number of citations of the paper that reports this interaction (PubMedID 10950869)
343

Data Source:
HPRD (in vivo, in vitro)

		BAK1	BID
Description		BCL2 antagonist/killer 1	BH3 interacting domain death agonist
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex Bcl-2 Family Protein Complex BAK Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane
	Molecular Function	Molecular_function Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Xenobiotic Stimulus Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Animal Organ Regeneration Positive Regulation Of Protein-containing Complex Assembly Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of IRE1-mediated Unfolded Protein Response	Release Of Cytochrome C From Mitochondria Response To Ischemia Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Response To Estradiol Positive Regulation Of Autophagy In Response To ER Overload Glial Cell Apoptotic Process Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Supramolecular Fiber Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria Pyroptosis	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464 22700719 24292274 23770605) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hematological parameters ( 19820697) Lung cancer ( 28604730) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Platelet count ( 26805783 22139419 24026423 29066854 23263863 29403010 33545615 32888494 22423221 25705162 20139978 27863252 28031487) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Schizophrenia ( 30285260) Spleen volume ( 34128465) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)	Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		20 interacting genes: ARHGDIA BAX BBS1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2	39 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB IL17RA MCL1 PITRM1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		578	637
HPRD ID		02744	03590
Ensembl ID		ENSG00000030110	ENSG00000015475
Uniprot IDs		A0A0S2Z391 Q16611	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		1BXL 2IMS 2IMT 2JBY 2JCN 2LP8 2M5B 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V 4UF1 5AJK 5FMI 5FMK 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX1 6ODH 6UXM 6UXN 6UXO 6UXP 6UXQ 6UXR	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F
Enriched GO Terms of Interacting Partners?
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