RBAK and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RBAK	PRKG1
Description		RB associated KRAB zinc finger	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Ca2+ pathway
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		28 interacting genes: AQP1 AR BYSL CARD9 CIB3 CRACR2A EFEMP2 EIF1AD FGF12 GAS8 L3MBTL2 LMO4 LNX1 MAGOHB NEK6 PRKG1 PRPF31 RB1 SCNM1 SLC25A10 TCAF1 TNS2 TRIM41 TSGA10 TXK ZNF121 ZNF330 ZNF648	39 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP WDR77 ZNF646
Entrez ID		57786	5592
HPRD ID		16296	08910
Ensembl ID		ENSG00000146587	ENSG00000185532
Uniprot IDs		Q9NYW8	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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