JCAD and IL2RA

		JCAD	IL2RA
Description		junctional cadherin 5 associated	interleukin 2 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Ruffle Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane
	Molecular Function		Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	Cell Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis	Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Inflammatory Response
Pathways			RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Coronary artery disease ( 30104761 33020668) Intraocular pressure ( 29617998) Myocardial infarction ( 33532862)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 22190364 24076602 19525953 19525955 17660530 21833088 27386562 28445677) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24449572 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480 30572963 22293688 18978792) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: IL2RA MAP3K8	17 interacting genes: AKR1C3 ARHGAP12 CALML3 CD4 FGF12 FKBP4 GTPBP4 ICAM1 IL2 IL2RB JCAD KIN NFKB1 PFKP SNTA1 STAT3 STAT5B
Entrez ID		57608	3559
HPRD ID		13864	00986
Ensembl ID		ENSG00000165757	ENSG00000134460
Uniprot IDs		Q9P266	P01589 Q5W005
PDB IDs			1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO
Enriched GO Terms of Interacting Partners?
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