KLHL8 and PNMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KLHL8	PNMT
Description		kelch like family member 8	phenylethanolamine N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cul3-RING Ubiquitin Ligase Complex	Cytosol
	Molecular Function		Phenylethanolamine N-methyltransferase Activity Protein Binding N-methyltransferase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Methylation Epinephrine Biosynthetic Process Catecholamine Biosynthetic Process
Pathways			Catecholamine biosynthesis
Drugs			S-adenosyl-L-homocysteine 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 33339817) Triglycerides ( 24097068 25961943 20686565)	Alcohol consumption ( 31358974) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bronchial hyperresponsiveness in asthma ( 27439200) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799 21297633) Urinary metabolites ( 26352407)
Interacting Genes		13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7	4 interacting genes: KLHL8 LNX1 TERF1 TERF2IP
Entrez ID		57563	5409
HPRD ID		13928	07176
Ensembl ID		ENSG00000145332	ENSG00000141744
Uniprot IDs		B3KY78 Q68DU9 Q7Z330 Q9P2G9	A8MT87 P11086
PDB IDs			1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72 2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCC 3HCD 3HCE 3HCF 3KPJ 3KPU 3KPV 3KPW 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2 4DM3 4MIK 4MQ4 6WS1
Enriched GO Terms of Interacting Partners?
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