MTUS1 and AGTR2

Number of citations of the paper that reports this interaction (PubMedID 15123706)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MTUS1	AGTR2
Description		microtubule associated scaffold protein 1	angiotensin II receptor type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton	Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Microtubule Binding	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Regulation Of Macrophage Chemotaxis	Positive Regulation Of Cytokine Production Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Cellular Sodium Ion Homeostasis Inflammatory Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Nitric Oxide Mediated Signal Transduction Brain Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Heart Rate Negative Regulation Of Norepinephrine Secretion Cerebellar Cortex Development Negative Regulation Of Cell Growth Negative Regulation Of Icosanoid Secretion Positive Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Positive Regulation Of Renal Sodium Excretion Aldosterone Secretion Angiotensin-activated Signaling Pathway Regulation Of Protein Import Into Nucleus Vasodilation Dopamine Biosynthetic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Kidney Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Dexamethasone Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Tasosartan CYT006-AngQb
Diseases
GWAS		Hippocampal volume in normal cognition ( 29274321) PR interval ( 32439900)	Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)
Interacting Genes		7 interacting genes: AGTR2 FBXO7 ORC4 SKP1 SOX7 STX5 STX7	11 interacting genes: ACE AGT AGTRAP ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		57509	186
HPRD ID		11376	02071
Ensembl ID		ENSG00000129422	ENSG00000180772
Uniprot IDs		Q9ULD2	P50052
PDB IDs			5UNF 5UNG 5UNH 6JOD
Enriched GO Terms of Interacting Partners?
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