ARID1B and MTHFD1L

		ARID1B	MTHFD1L
Description		AT-rich interaction domain 1B	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane SWI/SNF Complex Brahma Complex NBAF Complex	Mitochondrion Mitochondrial Matrix Cytosol Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nucleosome Binding	Formate-tetrahydrofolate Ligase Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity ATP Binding Protein Homodimerization Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription	Neural Tube Closure Folic Acid-containing Compound Metabolic Process 10-formyltetrahydrofolate Biosynthetic Process Formate Metabolic Process Tetrahydrofolate Interconversion Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Metabolism of folate and pterines
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease biomarkers ( 23419831) Calcium levels ( 24068962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Iris color (b* coordinate) ( 30895295) Lipoprotein (a) levels ( 26377243) Low density lipoprotein cholesterol levels ( 30498476) Multiple system atrophy (pathologically confirmed) ( 27629089) Pancreatic cancer ( 22158540) Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale) ( 28525603) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Type 2 diabetes ( 29621232) Vein graft stenosis in coronary artery bypass grafting ( 25881214) Western dietary pattern ( 28644415)	Alzheimer's disease (late onset) ( 20885792) Chronic myeloid leukemia ( 21540461) Coronary heart disease ( 17634449) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Type 2 diabetes ( 25760438)
Interacting Genes		15 interacting genes: ARMT1 CUL2 ENO1 GINM1 H2BC21 MAU2 MTHFD1L NCOA6 PLEKHG1 PYGM SMAD9 SMARCA2 SMARCA4 TNFRSF19 ZBTB2	2 interacting genes: ARID1B HGS
Entrez ID		57492	25902
HPRD ID		10660	09967
Ensembl ID		ENSG00000049618	ENSG00000120254
Uniprot IDs		Q8NFD5	A0A087WVM4 B2RD24 B7ZM99 Q6UB35
PDB IDs		2CXY 2EH9
Enriched GO Terms of Interacting Partners?
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