ZNF490 and TBX21

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ZNF490	TBX21
Description		zinc finger protein 490	T-box transcription factor 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Neuronal Cell Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Response To Virus T Cell Differentiation Negative Regulation Of Interleukin-2 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Isotype Switching To IgG Isotypes Cellular Response To Organic Substance Lymphocyte Migration Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654)	Ankylosing spondylitis ( 23749187) Asthma ( 30929738 34103634 31619474) Asthma (childhood onset) ( 31036433) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 22190364) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		34 interacting genes: CCDC136 CCNDBP1 CEP70 DTNBP1 FSD2 GLRX3 GOLGA6L9 HAP1 HOXB13 KRT40 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP12-3 LMNA LZTR1 LZTS2 MDFI MEOX2 MTUS2 NDEL1 RBMX RNPS1 STX1A TBX21 TEX19 TRAF1 TRIM41 TSGA10 VWC2 ZBTB32 ZC4H2 ZRANB1	3 interacting genes: EXOC5 HOXC11 ZNF490
Entrez ID		57474	30009
HPRD ID		15802	05355
Ensembl ID		ENSG00000188033	ENSG00000073861
Uniprot IDs		Q9ULM2	Q9UL17
PDB IDs
Enriched GO Terms of Interacting Partners?
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