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PTGS2 and CASK
Number of citations of the paper that reports this interaction (PubMedID
24722188
)
63
Data Source:
BioGRID
(two hybrid)
PTGS2
CASK
Description
prostaglandin-endoperoxide synthase 2
calcium/calmodulin dependent serine protein kinase
Image
GO Annotations
Cellular Component
Nuclear Inner Membrane
Nuclear Outer Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Caveola
Protein-containing Complex
Neuron Projection
Basement Membrane
Nuclear Lamina
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Basolateral Plasma Membrane
Nuclear Matrix
Vesicle
Presynaptic Membrane
Ciliary Membrane
Schaffer Collateral - CA1 Synapse
Molecular Function
Peroxidase Activity
Prostaglandin-endoperoxide Synthase Activity
Protein Binding
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Enzyme Binding
Heme Binding
Protein Homodimerization Activity
Metal Ion Binding
Guanylate Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Neurexin Family Protein Binding
Protein Serine Kinase Activity
Biological Process
Prostaglandin Biosynthetic Process
Angiogenesis
Inflammatory Response
Response To Oxidative Stress
Embryo Implantation
Aging
Learning
Memory
Regulation Of Blood Pressure
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Fructose
Response To Manganese Ion
Response To Lithium Ion
Positive Regulation Of Vascular Endothelial Growth Factor Production
Sensory Perception Of Pain
Cyclooxygenase Pathway
Bone Mineralization
Ovulation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
Positive Regulation Of Synaptic Plasticity
Negative Regulation Of Synaptic Transmission, Dopaminergic
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Vitamin D
Cellular Response To Heat
Response To Tumor Necrosis Factor
Cellular Response To UV
Maintenance Of Blood-brain Barrier
Positive Regulation Of Protein Import Into Nucleus
Hair Cycle
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Vasoconstriction
Negative Regulation Of Smooth Muscle Contraction
Positive Regulation Of Smooth Muscle Contraction
Decidualization
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Inflammatory Response
Brown Fat Cell Differentiation
Response To Glucocorticoid
Negative Regulation Of Calcium Ion Transport
Positive Regulation Of Synaptic Transmission, Glutamatergic
Response To Fatty Acid
Cellular Response To Mechanical Stimulus
Cellular Response To Lead Ion
Cellular Response To ATP
Cellular Response To Hypoxia
Cellular Response To Non-ionic Osmotic Stress
Cellular Response To Fluid Shear Stress
Positive Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Fibroblast Growth Factor Production
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Platelet-derived Growth Factor Production
Cellular Oxidant Detoxification
Regulation Of Neuroinflammatory Response
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To Angiotensin
Negative Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Cell Adhesion
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
GMP Metabolic Process
GDP Metabolic Process
Negative Regulation Of Wound Healing
Calcium Ion Import
Positive Regulation Of Calcium Ion Import
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Dopamine Neurotransmitter Release Cycle
Syndecan interactions
Nephrin family interactions
Neurexins and neuroligins
Neurexins and neuroligins
Assembly and cell surface presentation of NMDA receptors
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Dihomo-gamma-linolenic acid
Icosapent
Aminosalicylic acid
Mesalazine
Acetaminophen
Indomethacin
Nabumetone
Ketorolac
Tenoxicam
Lenalidomide
Celecoxib
Tolmetin
Rofecoxib
Piroxicam
Fenoprofen
Valdecoxib
Diclofenac
Sulindac
Flurbiprofen
Etodolac
Mefenamic acid
Naproxen
Sulfasalazine
Phenylbutazone
Meloxicam
Carprofen
Diflunisal
Suprofen
Salicylic acid
Meclofenamic acid
Acetylsalicylic acid
Bromfenac
Oxaprozin
Ketoprofen
Balsalazide
Thalidomide
Ibuprofen
Lumiracoxib
Magnesium salicylate
Salsalate
Choline magnesium trisalicylate
Ginseng
Antrafenine
Antipyrine
Tiaprofenic acid
Etoricoxib
Flufenamic acid
Resveratrol
1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
Prostaglandin G2
Niflumic acid
Licofelone
Nimesulide
Cimicoxib
Lornoxicam
Aceclofenac
Nepafenac
Parecoxib
Pomalidomide
Cannabidiol
Loxoprofen
Dexibuprofen
Dexketoprofen
Droxicam
Tolfenamic acid
Firocoxib
Morniflumate
Propacetamol
Talniflumate
Phenyl salicylate
Trolamine salicylate
Menthyl salicylate
Glycol salicylate
Dipyrithione
Bryostatin 1
Alclofenac
Bufexamac
Bendazac
Acemetacin
Fish oil
Medical Cannabis
Nabiximols
Formic acid
Fostamatinib
Diseases
GWAS
Crohn's disease (
26192919
)
Inflammatory bowel disease (
26192919
)
Knee osteoarthritis (
18471798
)
Interacting Genes
13 interacting genes:
ABHD16A
CASK
CAV1
CELF2
COPS5
COPS7A
CTNNB1
ELAVL1
GAS5
NUCB1
PTGIS
TP53
USP22
87 interacting genes:
AKAP9
APBA1
ATP2B4
BNIP3L
C20orf85
CADM1
CASKIN1
CDK9
CNTNAP2
CNTNAP4
DDX54
DLG1
DLG4
DUSP3
ELL2
EPB41
EPS8
ERBIN
F11R
FCHSD2
FMR1
GCNT3
GLS2
GRIK2
GRIN2A
GTSE1
HGS
ID1
IL15RA
IL18
KCNA4
KCNJ12
KCNJ2
KCNJ4
KIF2A
KLC4
LIN7A
LIN7B
MAPRE1
MAPRE2
MARK2
MARS1
MED1
MLLT6
MLX
NDEL1
NPHS1
NRXN1
NRXN2
NRXN3
NTN4
P2RX7
PARD3B
PARD6G
PCBP2
PCM1
PKP2
PLK2
PPP4R3A
PRC1
PRKCI
PRKD2
PRKN
PRPF3
PTGS2
RAB3A
RBBP6
RBM10
RBM14
RBM5
RPA2
RPH3A
SDC1
SDC2
SDC3
SDC4
SF3B2
SH2D4A
SLAIN2
SRPK2
TANC1
TBR1
TRIM22
TSPYL2
WHRN
WNT7B
YWHAE
Entrez ID
5743
8573
HPRD ID
02599
02164
Ensembl ID
ENSG00000073756
ENSG00000147044
Uniprot IDs
P35354
A0A2R8Y6F8
A0A2R8YE77
A0A7I2RJN6
O14936
PDB IDs
1V0X
5F19
5F1A
5IKQ
5IKR
5IKT
5IKV
5KIR
1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
3TAC
6KMH
Enriched GO Terms of Interacting Partners
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