PTEN and PLK1

  • Number of citations of the paper that reports this interaction (PubMedID 25047839)
  • 38
  • Data Source:
  • BioGRID (affinity chromatography technology, enzymatic study)

PTEN

PLK1

Description phosphatase and tensin homolog polo like kinase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Interacting Genes 377 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 AKT3 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARL3 ARMCX3 ASCC3 ATP5F1A ATP5F1C BCAR1 BEX1 BUB3 CACTIN-AS1 CAD CALM1 CAMK2G CAV1 CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COL18A1 COPA COPB1 COPS6 CREB1 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 CXXC1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EML1 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FGF7 FLNA FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 H2AX HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90AB1 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KIF20B KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LIPF LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDC1 MDN1 METTL26 MEX3C MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NCSTN NDFIP1 NEDD4 NGB NOP56 NOP58 NPM3 NR3C1 NUMB OSGIN1 OTUD3 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB PHB2 PICK1 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK2 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM15B RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 RYBP S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SLC9A3R1 SLC9A3R2 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SMURF1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP STUB1 SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TP53 TP53BP1 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2I UBE2L3 UPF1 USP7 USP9X UTP14A UTRN XRCC5 XRCC6 YAF2 YAP1 YES1 YTHDC2 YTHDF2 ZNF326 119 interacting genes: - ACTL6B APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 BUB1B C6orf136 CCDC115 CCNB1 CDC14A CDC25C CENPQ CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FBXW7 GET4 GLB1 GORASP1 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRBA1 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MPP2 MYC MYT1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PLK3 PPID PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PTEN PTPRD RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RXRA SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STK3 STUB1 SUGT1 TANK TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 USP16 USP7 VRK3 WEE1 ZNF71
Entrez ID 5728 5347
HPRD ID 03431 03652
Ensembl ID ENSG00000171862 ENSG00000166851
Uniprot IDs F6KD01 P60484 P53350
PDB IDs 1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ 1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?