PLXDC1 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		PLXDC1	C5AR2
Description		plexin domain containing 1	complement C5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Angiogenesis Spinal Cord Development	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways			Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Asthma ( 31619474) Tau burden ( 33426524)
Interacting Genes		4 interacting genes: C5AR2 GPR35 NID1 NRF1	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		57125	27202
HPRD ID		08439	17072
Ensembl ID		ENSG00000161381	ENSG00000134830
Uniprot IDs		Q8IUK5	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?
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