PSMD3 and ZBTB43

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		PSMD3	ZBTB43
Description		proteasome 26S subunit, non-ATPase 3	zinc finger and BTB domain containing 43
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GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Lid Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromatin Nucleus
	Molecular Function	Protein Binding Enzyme Regulator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity	Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 33730874) Asthma ( 31619474) Bipolar disorder ( 31043756) Creatine kinase levels ( 29403010) Lymphocyte percentage of white cells ( 32888494 27863252) Mitochondrial DNA copy number ( 30704525) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 25096241 20172861 29066854) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 25096241 29403010 22037903 20139978 21738480) White blood cell count (basophil) ( 27863252) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Eyebrow thickness ( 26926045)
Interacting Genes		15 interacting genes: BLM CDC42 CEP44 ERBB2 MED1 NFKBIA PRPF3 PSMA6 PSMD1 PSMD6 PSMD7 PTEN SEM1 TMEM14B ZBTB43	27 interacting genes: AEN AP1M1 ARR3 ARRB1 BDP1 CCDC13 CDKL3 CIB3 DDX6 DIP2A ELOA2 FAM161A LMO1 LMO3 LMO4 LNX1 MCM10 MORF4L1 MORF4L2 PSMD3 SYT6 TCEA2 TRAF2 ZBTB24 ZNF250 ZNF417 ZNF587
Entrez ID		5709	23099
HPRD ID		10170	08346
Ensembl ID		ENSG00000108344	ENSG00000169155
Uniprot IDs		O43242	O43298
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN	2CSH
Enriched GO Terms of Interacting Partners?
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