RGMA and SGSM2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RGMA	SGSM2
Description		repulsive guidance molecule BMP co-receptor a	small G protein signaling modulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Anchored Component Of Membrane Neuron Projection	Cytoplasm Melanosome
	Molecular Function	Protein Binding Coreceptor Activity Transferrin Receptor Binding	GTPase Activator Activity Small GTPase Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Neuron Projection Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Neuron Projection Development Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Receptor Binding	Intracellular Protein Transport Late Endosome To Golgi Transport Positive Regulation Of GTPase Activity Activation Of GTPase Activity
Pathways		Netrin-1 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Copper levels ( 26025379) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Opioid dependence ( 29478698) Overweight status ( 25133637) Periodontitis (CDC/AAP) ( 24024966) Refractive error ( 32231278) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Type 1 diabetes nephropathy ( 23028342) Type 2 diabetes ( 32499647)	Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fasting blood proinsulin levels ( 23263489) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Proinsulin levels ( 21873549) Schizophrenia ( 25056061)
Interacting Genes		5 interacting genes: CRTC3 PPP1R16A SGSM2 TERF2IP TP53BP2	20 interacting genes: AFP CA12 CELSR3 CHD3 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 MTDH PNO1 PTN RAB2A RAB2B RAB3A RAB3B RAB9B RGMA RPS25
Entrez ID		56963	9905
HPRD ID		09560	15284
Ensembl ID		ENSG00000182175	ENSG00000141258
Uniprot IDs		A0A0A0MTQ4 Q96B86	B9A6J3 O43147
PDB IDs		4UHY 6Z3G
Enriched GO Terms of Interacting Partners?
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