RAD18 and POLK

Number of citations of the paper that reports this interaction (PubMedID 21396873)
88

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RAD18	POLK
Description		RAD18 E3 ubiquitin protein ligase	DNA polymerase kappa
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Cellular Response To UV Error-prone Translesion Synthesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins	Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Iron status biomarkers (transferrin saturation) ( 28334935)
Interacting Genes		29 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 MAGEA4 MAP3K1 MAPK8 MLKL NBN ORC2 PCGF6 PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		56852	51426
HPRD ID		09242	09291
Ensembl ID		ENSG00000070950	ENSG00000122008
Uniprot IDs		Q9NS91	A0A024RAP4 Q9UBT6
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST
Enriched GO Terms of Interacting Partners?
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