TRIM39 and ZKSCAN4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TRIM39	ZKSCAN4
Description		tripartite motif containing 39	zinc finger with KRAB and SCAN domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		62 interacting genes: APP BTNL2 CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	23 interacting genes: CABP5 IL36RN LXN MDM4 MEOX2 OGT OSGIN1 PGBD1 PSMA6 SCAND1 TIAM1 TRIM39 ZKSCAN7 ZNF24 ZNF397 ZNF446 ZNF483 ZNF496 ZSCAN20 ZSCAN21 ZSCAN22 ZSCAN30 ZSCAN32
Entrez ID		56658	387032
HPRD ID		09298	15768
Ensembl ID		ENSG00000204599	ENSG00000187626
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	A0A0S2Z658 B7Z7H3 Q969J2
PDB IDs		2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?
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