INPP5E and EXD3

		INPP5E	EXD3
Description		inositol polyphosphate-5-phosphatase E	exonuclease 3'-5' domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Axoneme Golgi Cisterna Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity	Nucleic Acid Binding Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Biological_process Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Translation Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Protein Localization To Cilium	Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Granulocyte count ( 27863252) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Red cell distribution width ( 32888494) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823 27494321) Loneliness ( 27629369) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Multisite chronic pain ( 33830993 31194737) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: EXD3 KTN1 YWHAG	3 interacting genes: DAZAP2 INPP5E PLSCR1
Entrez ID		56623	54932
HPRD ID		17151	07906
Ensembl ID		ENSG00000148384	ENSG00000187609
Uniprot IDs		Q9NRR6	Q8N9H8
PDB IDs		2XSW
Enriched GO Terms of Interacting Partners?
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