LGMN and USP17L2

Number of citations of the paper that reports this interaction (PubMedID 24610907)
34

Data Source:
BioGRID (enzymatic study, biochemical, affinity chromatography technology)

		LGMN	USP17L2
Description		legumain	ubiquitin specific peptidase 17 like family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity Tau Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Activation Of Cysteine-type Endopeptidase Activity Self Proteolysis Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis	MAPK Cascade Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Histone Deacetylation Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation	Ub-specific processing proteases RAS processing
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Change in serum metabolite levels (CMS) ( 31636271) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		6 interacting genes: FBLN5 LAMC3 MAPT SET SRPK2 USP17L2	9 interacting genes: BRD4 CDK4 CDK6 ELK1 KMT5A LGMN LINC02487 SNAI1 UBC
Entrez ID		5641	377630
HPRD ID		04017	16844
Ensembl ID		ENSG00000100600	ENSG00000223443
Uniprot IDs		Q53XC6 Q96CY7 Q99538	Q6R6M4
PDB IDs		4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB
Enriched GO Terms of Interacting Partners?
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