PROS1 and F5

Number of citations of the paper that reports this interaction (PubMedID 8428962)
40

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PROS1	F5
Description		protein S	coagulation factor V
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity Fibrinolysis	Blood Coagulation Blood Circulation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases
GWAS		Systemic lupus erythematosus ( 28714469)	Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Ischemic stroke ( 26732560) Macrovascular complications in type 2 diabetes ( 33430853) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 33592630 21980494 23650146 25772935 32232851 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		12 interacting genes: ARL6 C4BPA C4BPB F10 F2 F5 F8 HSP90AB1 PROC RPSA TBK1 TYRO3	13 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 FCER1G FCGR2A MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		5627	2153
HPRD ID		01473	01964
Ensembl ID		ENSG00000184500	ENSG00000198734
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	P12259
PDB IDs		1Z6C	1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C
Enriched GO Terms of Interacting Partners?
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