MRAP and MC2R

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MRAP	MC2R
Description		melanocortin 2 receptor accessory protein	melanocortin 2 receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Regulation Of Metabolic Process
Pathways			Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes obesity and POMCD ADORA2B mediated anti-inflammatory cytokines production
Drugs			Tetracosactide Corticotropin Seractide acetate Bremelanotide
Diseases
GWAS			Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		1 interacting genes: MC2R	4 interacting genes: ASIP MRAP MRAP2 POMC
Entrez ID		56246	4158
HPRD ID		10758	06304
Ensembl ID		ENSG00000170262	ENSG00000185231
Uniprot IDs		Q8TCY5	Q01718
PDB IDs
Enriched GO Terms of Interacting Partners?
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