PDGFC and ST14

Number of citations of the paper that reports this interaction (PubMedID 22035541)
22

Data Source:
BioGRID (enzymatic study)

		PDGFC	ST14
Description		platelet derived growth factor C	ST14 transmembrane serine protease matriptase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity Growth Factor Receptor Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Central Nervous System Development Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Embryonic Organ Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis	Neural Tube Closure Proteolysis Keratinocyte Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching
Pathways			Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 34074324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypospadias ( 25108383) Immature fraction of reticulocytes ( 32888494) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Monocyte count ( 32888494) Motor coordination ( 34177493) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1	18 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF NFRKB NOTCH2 PDGFC PHB PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		56034	6768
HPRD ID		10529	06005
Ensembl ID		ENSG00000145431	ENSG00000149418
Uniprot IDs		Q9NRA1	Q9Y5Y6
PDB IDs			1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T
Enriched GO Terms of Interacting Partners?
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