BRK1 and MRFAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BRK1	MRFAP1
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	Morf4 family associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Nucleoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)
Interacting Genes		10 interacting genes: BRAP CYFIP2 HSBP1 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	41 interacting genes: ABI1 ABI2 ABI3 BRK1 C14orf93 C3orf62 C8orf33 CAVIN3 CCDC146 DCDC2 DNAJB5 DPY30 FCHSD2 GOLGA8F GOLGA8G HTT KIFC3 MAP1LC3B MORF4L1 MORF4L2 MRFAP1L1 MTIF3 PAM16 PCBD2 PRAP1 PRKAA2 SDCBP SH2D4A SMU1 SUV39H2 TEX11 TK1 TPM2 TRIM47 TXN TXN2 UBTD1 UQCC2 WASHC1 ZDHHC17 ZNF655
Entrez ID		55845	93621
HPRD ID		12818	17589
Ensembl ID		ENSG00000254999	ENSG00000179010
Uniprot IDs		Q8WUW1	A0A087WTY9 B3KQA0 Q9Y605
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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