PAG1 and GLS2

Number of citations of the paper that reports this interaction (PubMedID 11163757)
16

Data Source:
HPRD (in vitro)

		PAG1	GLS2
Description		phosphoprotein membrane anchor with glycosphingolipid microdomains 1	glutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Membrane Raft	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Glutaminase Activity Protein Binding
	Biological Process	Adaptive Immune Response Signal Transduction Intracellular Signal Transduction Regulation Of T Cell Activation Negative Regulation Of T Cell Activation	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Health literacy ( 31250787) Serum total protein level ( 23022100)	Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		17 interacting genes: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN PTPN11 PTPN6 RASA1 SHC1 SLC9A3R1 SYK VAV1 ZAP70	17 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 OS9 PAG1 PATJ PDE2A RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1
Entrez ID		55824	27165
HPRD ID		05772	05901
Ensembl ID		ENSG00000076641	ENSG00000135423
Uniprot IDs		Q9NWQ8	A0A087X004 Q9UI32
PDB IDs			4BQM 5U0K
Enriched GO Terms of Interacting Partners?
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