PRKCD and RAF1

  • Number of citations of the paper that reports this interaction (PubMedID 11171046)
  • 18
  • Data Source:
  • HPRD (in vitro)

PRKCD

RAF1

Description protein kinase C delta Raf-1 proto-oncogene, serine/threonine kinase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Bipolar disorder ( 21926972)
  • Body shape index ( 34021172)
  • Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083)
  • Ulcerative colitis ( 23128233)
  • Waist circumference adjusted for body mass index ( 28552196 34021172)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
  • Asthma ( 32296059)
  • Body shape index ( 34021172)
  • Cardiac hypertrophy ( 21348951)
  • Carotid intima media thickness x smoking interaction ( 32117412)
  • Cholesterol, total ( 24097068 20686565)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • HDL cholesterol levels ( 32203549)
  • Hip index ( 34021172)
  • Total cholesterol levels ( 28334899)
  • Waist circumference adjusted for body mass index ( 34021172)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes 121 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NSD1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ 160 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 EGFR EPHA2 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HERC1 HGF HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 ITCH JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LOX LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MBP MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TSC22D3 UBE2D2 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1
Entrez ID 5580 5894
HPRD ID 01501 01265
Ensembl ID ENSG00000163932 ENSG00000132155
Uniprot IDs A0A024R328 B4DFV1 Q05655 A0A0S2Z4L5 L7RRS6 P04049
PDB IDs 1YRK 2YUU 1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL 6NTC 6NTD 6PTS 6PTW 6VJJ 6XGU 6XGV 6XHA 6XHB 6XI7 7JHP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?