AXL and IL15RA

Number of citations of the paper that reports this interaction (PubMedID 16308569)
18

Data Source:
HPRD (in vitro, in vivo)

		AXL	IL15RA
Description		AXL receptor tyrosine kinase	interleukin 15 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Actin Cytoskeleton Intracellular Membrane-bounded Organelle Receptor Complex Host Cell Surface Extracellular Exosome	Golgi Membrane Extracellular Space Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Positive Regulation Of Kinase Activity Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process	Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		VEGFA-VEGFR2 Pathway	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Fostamatinib Gilteritinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731)	Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Neuroblastoma (pediatric) ( 32599975) Soluble interleukin-2 receptor subunit alpha ( 26293465)
Interacting Genes		23 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		558	3601
HPRD ID		00171	03045
Ensembl ID		ENSG00000167601	ENSG00000134470
Uniprot IDs		M0R0W6 P30530	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		2C5D 4RA0 5U6B 5VXZ	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?
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