ARHGEF40 and TAC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		ARHGEF40	TAC1
Description		Rho guanine nucleotide exchange factor 40	tachykinin precursor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Substance P Receptor Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs
Diseases
GWAS		Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)	Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1	12 interacting genes: ARHGEF40 BAG6 CDK6 CENPB FN1 MEP1A PREP SGCE TACR1 TACR2 TACR3 XRCC6
Entrez ID		55701	6863
HPRD ID		13335	08876
Ensembl ID		ENSG00000165801	ENSG00000006128
Uniprot IDs		Q8TER5	P20366 Q9Y494
PDB IDs			2B19 2KS9 2KSA 2KSB 4HOM
Enriched GO Terms of Interacting Partners?
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