LYAR and TERF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
51

Data Source:
BioGRID (two hybrid)

		LYAR	TERF2
Description		Ly1 antibody reactive	telomeric repeat binding factor 2
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Nuclear Body Shelterin Complex Axon Cytoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Protein C-terminus Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis	Telomere Maintenance In Utero Embryonic Development RNA-dependent DNA Biosynthetic Process Cell Cycle Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Nitric-oxide Synthase Activity Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Beta-galactosidase Activity Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration ( 29346644)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Daytime nap ( 33568662) Leukocyte telomere length ( 32109421) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)
Interacting Genes		14 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PHF20L1 PRKRA SDCBP2 SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1	59 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NUTF2 NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18
Entrez ID		55646	7014
HPRD ID		10064	03610
Ensembl ID		ENSG00000145220	ENSG00000132604
Uniprot IDs		Q9NX58	Q15554
PDB IDs		6ZMI 6ZMO 6ZVH	1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D
Enriched GO Terms of Interacting Partners?
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