SMPD4 and NR4A2

		SMPD4	NR4A2
Description		sphingomyelin phosphodiesterase 4	nuclear receptor subfamily 4 group A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Integral Component Of Membrane Sarcolemma	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Glucocorticoid Receptor Binding Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Sphingomyelin Catabolic Process Endoplasmic Reticulum Organization Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Signal Transduction Adult Locomotory Behavior Post-embryonic Development Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Glycosphingolipid metabolism	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Phosphatidyl serine
Diseases
GWAS			Age at voice drop ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Chronic obstructive pulmonary disease ( 30804561) Depression ( 29700475) HDL cholesterol levels ( 32109663) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Menarche (age at onset) ( 21102462 25231870) Response to statin therapy ( 20339536) Schizophrenia ( 33169155) Sociability score ( 34054130) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		4 interacting genes: CFC1 ERBB2 EXOSC4 NR4A2	18 interacting genes: BAZ1B CDKN1C CDKN2D CHST13 COPS5 FAP MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 SMPD4 TCEAL5 VHL
Entrez ID		55627	4929
HPRD ID		13374	03493
Ensembl ID		ENSG00000136699	ENSG00000153234
Uniprot IDs		Q9NXE4	F1D8N6 F1DAL2 P43354 Q53EL4
PDB IDs			1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q
Enriched GO Terms of Interacting Partners?
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