PRKAA1 and PRKAB1

Number of citations of the paper that reports this interaction (PubMedID 8626596)
65

Data Source:
HPRD (in vitro, two hybrid)

		PRKAA1	PRKAB1
Description		protein kinase AMP-activated catalytic subunit alpha 1	protein kinase AMP-activated non-catalytic subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Histone Serine Kinase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity Protein Serine Kinase Activity	Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Response To Hypoxia Glucose Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Signal Transduction Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Bile Acid And Bile Salt Transport Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Bile Acid Signaling Pathway Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Energy Homeostasis Regulation Of Bile Acid Secretion Response To Camptothecin Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Cellular Protein Localization Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Tubulin Deacetylation Response To 17alpha-ethynylestradiol Positive Regulation Of Peptidyl-lysine Acetylation	Protein Phosphorylation Fatty Acid Biosynthetic Process Signal Transduction Positive Regulation Of Gene Expression Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib	Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26701879 26129866)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		68 interacting genes: ABI2 ACACA AGAP2 BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TLE5 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2
Entrez ID		5562	5564
HPRD ID		04115	04116
Ensembl ID		ENSG00000132356	ENSG00000111725
Uniprot IDs		Q13131	A0A024RBN1 Q9Y478
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J	4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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