MAML3 and ZBTB1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		MAML3	ZBTB1
Description		mastermind like transcriptional coactivator 3	zinc finger and BTB domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Centrosome Nuclear Body Nuclear Membrane
	Molecular Function	Transcription Coactivator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Mediated Immunity DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Translesion Synthesis Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To UV MRNA Transcription By RNA Polymerase II Innate Immune Response Positive Regulation Of T Cell Differentiation Thymus Development Protein Homooligomerization Positive Regulation Of Pro-T Cell Differentiation
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Smoking initiation ( 33082346) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Walking pace ( 33128006)	Lymphocyte counts ( 32888494) Neutrophil percentage of white cells ( 32888494) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3	22 interacting genes: AKR7A2 AR EWSR1 FAM161A FANCG HEMGN KAT5 LZTR1 MAML3 MFAP1 NDN PCNA PIH1D2 PIM1 SCNM1 TRAF1 TRIM42 UBC UBE2I ZBTB25 ZNF417 ZNF572
Entrez ID		55534	22890
HPRD ID		10066	15688
Ensembl ID		ENSG00000196782	ENSG00000126804
Uniprot IDs		Q96JK9 Q9NPV6	Q9Y2K1
PDB IDs
Enriched GO Terms of Interacting Partners?
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