AVPR2 and FXYD6-FXYD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AVPR2	FXYD6-FXYD2
Description		arginine vasopressin receptor 2	FXYD6-FXYD2 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Telencephalon Development Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction
Pathways		Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin
Diseases
GWAS			Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		10 interacting genes: ARRB2 AVP C1QTNF1 COMT FXYD6-FXYD2 GNAS GNB1 GNG2 GRK5 SLC41A1	33 interacting genes: APH1B APOL3 AQP6 AVPR2 BEST1 BNIP3 CERS4 CLDN5 FAM210B GPR152 GPR37L1 GPRC5D MTIF3 PGRMC2 RNF170 SLC10A1 SLC10A6 SLC16A13 SLC19A3 SLC2A13 SLC34A2 SLC35C2 SLC7A8 SPCS1 TLCD4 TMEM14B TMEM167B TMEM205 TMEM41A TMPPE TMX2 TRHR UNC93A
Entrez ID		554	100533181
HPRD ID		02368
Ensembl ID		ENSG00000126895	ENSG00000255245
Uniprot IDs		P30518	A0A087WZ82 A0A0A6YYL5
PDB IDs		4JQI 6NI2 6U1N
Enriched GO Terms of Interacting Partners?
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