STYK1 and PIK3C3

Number of citations of the paper that reports this interaction (PubMedID 31696776)
4

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		STYK1	PIK3C3
Description		serine/threonine/tyrosine kinase 1	phosphatidylinositol 3-kinase catalytic subunit type 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Innate Immune Response	Autophagosome Assembly Protein Phosphorylation Protein Lipidation Endocytosis Autophagy Endosome Organization Cell Cycle Macroautophagy Protein Processing Autophagy Of Peroxisome Regulation Of Cytokinesis Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To Leucine Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion Cell Division
Pathways			PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs			N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Diseases
GWAS			Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) Frailty index ( 34431594) General risk tolerance (MTAG) ( 30643258) Major depressive disorder (MTAG) ( 33479212) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966) Walking pace ( 33128006)
Interacting Genes		5 interacting genes: ATG14 BECN1 DUXAP9 ERBB2 PIK3C3	10 interacting genes: CALM1 CASP8 FBXL20 OTUD7B PDPK1 PIK3R4 PITPNA STYK1 YWHAG YWHAQ
Entrez ID		55359	5289
HPRD ID		15447	04009
Ensembl ID		ENSG00000060140	ENSG00000078142
Uniprot IDs		Q6J9G0	A8MYT4 B4DPV9 Q8NEB9
PDB IDs			3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U 7BL1
Enriched GO Terms of Interacting Partners?
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