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TCP11L1 and PSMD4
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
TCP11L1
PSMD4
Description
t-complex 11 like 1
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Image
No pdb structure
GO Annotations
Cellular Component
Microtubule
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
Protein Binding
RNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Biological Process
Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Anger (
24489884
)
Platelet distribution width (
32888494
)
Body mass index (
26426971
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
24 interacting genes:
APP
CNOT7
DDIT4L
ERCC6L2
HMG20A
IKBKG
IPO4
LHX2
MAGEA12
MEOX1
NEDD4
OGT
PAX6
PLEKHS1
PRXL2B
PSMD4
REL
SDCBP2
SNW1
TBX6
TRIM21
TSNAX
VPS52
WWTR1
46 interacting genes:
ADRM1
APP
BTRC
CCNA2
CUL1
EGFR
FBXO25
FLOT1
GNB5
H2AC4
H2BC3
ID1
MAP3K1
MDM2
MYOD1
NEDD4
NEDD4L
NEDD8
NUB1
OGT
PRKN
PSMC3
PSMD7
PTEN
RAD23A
RAD23B
RASSF8
RBCK1
SCHIP1
SIAH2
SMURF1
SREBF2
STUB1
TCF3
TCP11L1
TMEM129
TP53
TRIM63
UBB
UBC
UBD
UBE2C
UBQLN1
UBQLN2
USP7
XPC
Entrez ID
55346
5710
HPRD ID
07750
03386
Ensembl ID
ENSG00000176148
ENSG00000159352
Uniprot IDs
B3KQZ4
Q9NUJ3
P55036
Q5VWC4
PDB IDs
1P9C
1P9D
1UEL
1YX4
1YX5
1YX6
2KDE
2KDF
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6MUN
6U19
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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