PPP3R1 and CHRNA6

Number of citations of the paper that reports this interaction (PubMedID 27107012)
40

Data Source:
BioGRID (two hybrid)

		PPP3R1	CHRNA6
Description		protein phosphatase 3 regulatory subunit B, alpha	cholinergic receptor nicotinic alpha 6 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma Schaffer Collateral - CA1 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding	Protein Binding Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Dephosphorylation Protein Import Into Nucleus Heart Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Lung Epithelial Cell Differentiation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Myristic acid Voclosporin	Nicotine Butabarbital Ethanol Varenicline Cytisine
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)	Nicotine dependence ( 26440539) Pelvic organ prolapse (moderate/severe) ( 26545240) Smoking behavior ( 20418888)
Interacting Genes		11 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC WDPCP	1 interacting genes: PPP3R1
Entrez ID		5534	8973
HPRD ID		03195	06056
Ensembl ID		ENSG00000221823	ENSG00000147434
Uniprot IDs		P63098	Q15825
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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