TMEM140 and CLDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM140	CLDN5
Description		transmembrane protein 140	claudin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process		Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier
Pathways			Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS
Interacting Genes		50 interacting genes: APH1A AQP6 ASGR2 CD22 CD53 CD79A CGRRF1 CLDN5 CLDN7 CLEC17A CLRN1 CREB3 EBP FAM209A FAM210B FCER1G FNDC9 GOLM1 GPR152 GPR42 HHLA2 HSD17B13 IFNGR2 KCNJ8 KRTAP10-8 LMNA LY6E MFF MGST3 MILR1 MS4A3 MSMO1 PDZK1IP1 PSCA RMDN3 SCN3B SHISAL1 SIT1 SLC39A9 SPACA1 STOM SYNE4 TEX29 TMEM182 TMEM205 TMEM207 TMEM9 TMX2 TSPAN12 TSPO2	40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1
Entrez ID		55281	7122
HPRD ID		07723	03654
Ensembl ID		ENSG00000146859	ENSG00000184113
Uniprot IDs		Q9NV12	D3DX19 O00501
PDB IDs
Enriched GO Terms of Interacting Partners?
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