TMEM100 and CD33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM100	CD33
Description		transmembrane protein 100	CD33 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Perikaryon Perinuclear Region Of Cytoplasm	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Notch Signaling Pathway BMP Signaling Pathway Protein Kinase B Signaling Positive Regulation Of Endothelial Cell Differentiation Regulation Of Calcium-mediated Signaling Regulation Of Sensory Perception Of Pain Arterial Endothelial Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Vasculogenesis	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Secretion Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Height ( 22021425) Pulse pressure ( 30578418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)
Interacting Genes		33 interacting genes: AQP6 CCDC57 CD33 CLDN7 COMT CREB3 EBP ERGIC3 F11R FAM209A FNDC9 GJA8 GPR152 HSD17B13 IFNGR1 JAGN1 LHFPL5 MEOX2 NUP93 REEP1 RETREG3 RMDN3 RNF19B SLC30A4 SLC35A5 STING1 STX1A TMEM130 TMEM167B TMEM52B TMEM79 TMEM80 VSIR	22 interacting genes: BBS9 BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1
Entrez ID		55273	945
HPRD ID		07719	01165
Ensembl ID		ENSG00000166292	ENSG00000105383
Uniprot IDs		Q9NV29	P20138 Q546G0
PDB IDs			5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?
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