NUDT15 and UTP14C

		NUDT15	UTP14C
Description		nudix hydrolase 15	UTP14C small subunit processome component
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DTTP Diphosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity	Protein Binding
	Biological Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process	RRNA Processing Spermatogenesis Cell Differentiation Meiotic Cell Cycle
Pathways		Phosphate bond hydrolysis by NUDT proteins	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		6 interacting genes: CDADC1 FNDC3A GABARAPL2 MTRF1 SRD5A3 UTP14C	32 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 NUDT15 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA
Entrez ID		55270	9724
HPRD ID		14848	12346
Ensembl ID		ENSG00000136159	ENSG00000253797
Uniprot IDs		Q9NV35	A0A024RDV0 Q5TAP6
PDB IDs		5BON 5LPG 6T5J
Enriched GO Terms of Interacting Partners?
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