PPP2CB and GSTA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PPP2CB	GSTA1
Description		protein phosphatase 2 catalytic subunit beta	glutathione S-transferase alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol	Cytosol Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Tau Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Glutathione Transferase Activity Glutathione Peroxidase Activity Steroid Delta-isomerase Activity Fatty Acid Binding
	Biological Process	Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Peptidyl-serine Dephosphorylation Positive Regulation Of Microtubule Binding	Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Epithelial Cell Differentiation Linoleic Acid Metabolic Process Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Glutathione conjugation Heme degradation
Drugs		Vitamin E	Glutathione S-Hydroxycysteine 2-Hydroxyethyl Disulfide N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine Glutathione sulfonic acid Glutathione disulfide S-benzylglutathione S-Hexylglutathione Hypericin
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Blood protein levels ( 29875488) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 33339817)
Interacting Genes		44 interacting genes: ACP5 AURKA AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR FGFR1 GAD1 GSTA1 HK3 ICOSLG KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLAT PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	7 interacting genes: APP GSTA2 LSM3 PPP2CB RPAIN ST3GAL1 YWHAE
Entrez ID		5516	2938
HPRD ID		01487	00708
Ensembl ID		ENSG00000104695	ENSG00000243955
Uniprot IDs		A0A140VJS0 P62714	A0A140VJK4 B7Z1F9 P08263
PDB IDs			1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V 3ZFB 3ZFL 4HJ2 5JCU 5LCZ 5LD0 6ATO 6ATP 6ATQ 6ATR 6YAW
Enriched GO Terms of Interacting Partners?
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