VPS37C and RFX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		VPS37C	RFX6
Description		VPS37C subunit of ESCRT-I	regulatory factor X6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Endosome Membrane Late Endosome Membrane Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)	Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 20676098 31562322 26443449) Serum total protein level ( 29403010) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34	41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PPP1R32 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688
Entrez ID		55048	222546
HPRD ID		15652	11490
Ensembl ID		ENSG00000167987	ENSG00000185002
Uniprot IDs		A5D8V6	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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