CDCA4 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CDCA4	SHC3
Description		cell division cycle associated 4	SHC adaptor protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Protein Binding Transcription Regulator Activity	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Chromatin-mediated Maintenance Of Transcription	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction
Pathways			Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)	Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		25 interacting genes: BFSP2 C1orf109 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451	58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12
Entrez ID		55038	53358
HPRD ID		13015	12005
Ensembl ID		ENSG00000170779	ENSG00000148082
Uniprot IDs		A0A024R6P3 Q9BXL8	Q92529
PDB IDs
Enriched GO Terms of Interacting Partners?
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