PIH1D1 and RPAP2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		PIH1D1	RPAP2
Description		PIH1 domain containing 1	RNA polymerase II associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol RNA Polymerase II, Holoenzyme
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding	Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity RNA Polymerase Core Enzyme Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Box C/D SnoRNP Assembly RNA Polymerase I Preinitiation Complex Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly SnoRNA Localization Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	SnRNA Transcription Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways			RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS			Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 27863252) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494 27863252) Type 1 diabetes ( 34127860)
Interacting Genes		20 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM LRCH3 MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 RPAP2 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4	5 interacting genes: GPN1 ITCH NEDD4 PIH1D1 PLEKHF2
Entrez ID		55011	79871
HPRD ID		07938	07814
Ensembl ID		ENSG00000104872	ENSG00000122484
Uniprot IDs		Q9NWS0	Q8IXW5
PDB IDs		4PSF 4PSI 6GXZ 7AVC
Enriched GO Terms of Interacting Partners?
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