PINX1 and RP1L1

		PINX1	RP1L1
Description		PIN2 (TERF1) interacting telomerase inhibitor 1	RP1 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle	Photoreceptor Outer Segment Microtubule Axoneme Photoreceptor Connecting Cilium
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus	Visual Perception Axoneme Assembly Intracellular Signal Transduction Photoreceptor Cell Development Photoreceptor Cell Maintenance Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Heart rate response to exercise ( 29769521) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 30275531) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Osteoarthrosis (time to event) ( 32589924) Processed meat consumption ( 32066663) Red cell distribution width ( 32888494) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: AIDA APP ARHGEF10 BNIP1 C14orf119 CACYBP DLGAP2 EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 PTP4A3 RP1L1 TERF1 TERT TLK1 TNPO2 TP63 UBL5	2 interacting genes: PINX1 SOX4
Entrez ID		54984	94137
HPRD ID		05934	10546
Ensembl ID		ENSG00000254093	ENSG00000183638
Uniprot IDs		Q96BK5	Q8IWN7
PDB IDs
Enriched GO Terms of Interacting Partners?
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