PPL and ACTR5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPL	ACTR5
Description		periplakin	actin related protein 5
Image
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Ino80 Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription, DNA-templated UV-damage Excision Repair
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Schizophrenia ( 25056061 29483656)
Interacting Genes		45 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 LARP1 MRPL28 OPRM1 PBX4 PICK1 PKD1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	2 interacting genes: CSNK2B PPL
Entrez ID		5493	79913
HPRD ID		04187	08575
Ensembl ID		ENSG00000118898	ENSG00000101442
Uniprot IDs		O60437	Q9H9F9
PDB IDs		4Q28	6HTS
Enriched GO Terms of Interacting Partners?
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