ELOVL2 and IFITM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ELOVL2	IFITM3
Description		ELOVL fatty acid elongase 2	interferon induced transmembrane protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity	Protein Binding
	Biological Process	Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process	Immune Response Response To Virus Negative Regulation Of Viral Transcription Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs	Interferon alpha/beta signaling
Drugs		alpha-Linolenic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Glycerophospholipid levels ( 26068415) Metabolic traits ( 21886157) Metabolite levels ( 22916037) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum metabolite ratios in chronic kidney disease ( 29545352)	Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252)
Interacting Genes		4 interacting genes: FXYD6 IFITM3 MALL TMEM218	27 interacting genes: ABHD16A AQP6 CD53 ELOVL2 ERGIC3 FAM210B FFAR2 FKBP7 GLP1R GPR37 GPRC5D KIR2DL3 LYPD5 MS4A3 NEDD4 OPRM1 PLP1 PTAFR REEP4 RETREG3 SGPL1 SLC10A1 SLC10A2 SLC16A7 TMEM14B TMEM86B VKORC1
Entrez ID		54898	10410
HPRD ID		16857	05719
Ensembl ID		ENSG00000197977	ENSG00000142089
Uniprot IDs		A0A024QZV3 Q9NXB9	Q01628
PDB IDs
Enriched GO Terms of Interacting Partners?
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