MFSD6 and MSTN

		MFSD6	MSTN
Description		major facilitator superfamily domain containing 6	myostatin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Negative Regulation Of Kinase Activity Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways			FOXO-mediated transcription of cell cycle genes
Drugs			MYO-029
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)	Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)
Interacting Genes		43 interacting genes: ADIPOQ ALG8 ANKAR APH1A APOL3 AQP7 C19orf18 C2orf88 CD79A CYB5R3 EBP ERGIC3 GJA8 GJB2 GPR152 GPR42 GPX8 HIBCH LY6E MFSD4B MSTN NKG7 OSGEPL1 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SMIM1 SSMEM1 STAT1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2 WDR75	7 interacting genes: ACVR2B APP FSTL3 MFSD6 SGTA TCAP WFIKKN2
Entrez ID		54842	2660
HPRD ID		13369	03474
Ensembl ID		ENSG00000151690	ENSG00000138379
Uniprot IDs		Q6ZSS7	O14793 Q53S46
PDB IDs			5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?
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