GATAD2A and ISYNA1

		GATAD2A	ISYNA1
Description		GATA zinc finger domain containing 2A	inositol-3-phosphate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding	Inositol-3-phosphate Synthase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated	Inositol Biosynthetic Process Phospholipid Biosynthetic Process
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)	Alzheimer's disease (late onset) ( 30820047) Blood metabolite levels ( 24816252) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)
Interacting Genes		22 interacting genes: ARRDC2 BABAM1 BST2 CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 ISYNA1 ITGB3BP KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 RASA2 SPOP TMEM161A	6 interacting genes: DUSP14 GATAD2A OGT POT1 PPP2CA TRAF4
Entrez ID		54815	51477
HPRD ID		11741	17163
Ensembl ID		ENSG00000167491	ENSG00000105655
Uniprot IDs		A0A024R7K7 A0A024R7M6 Q86YP4	A0A140VK73 Q9NPH2
PDB IDs		2L2L
Enriched GO Terms of Interacting Partners?
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