CTSA and CSPG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CTSA	CSPG5
Description		cathepsin A	chondroitin sulfate proteoglycan 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Golgi-associated Vesicle Membrane Lysosomal Lumen Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity	Protein Binding Growth Factor Activity
	Biological Process	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	Cytoskeleton Organization Signal Transduction Nervous System Development Regulation Of Growth Intracellular Transport Cell Projection Morphogenesis Trans-synaptic Signaling, Modulating Synaptic Transmission Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synaptic Vesicle Exocytosis
Pathways		Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS			Body mass index ( 29273807) Smoking initiation ( 33082346)
Interacting Genes		45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2	3 interacting genes: CTSA ERBB3 GOPC
Entrez ID		5476	10675
HPRD ID		02020	08423
Ensembl ID		ENSG00000064601	ENSG00000114646
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	A0A087WUT8 B7Z2E0 O95196
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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