ATRX and NEK1

Number of citations of the paper that reports this interaction (PubMedID 14690447)
34

Data Source:
HPRD (two hybrid)

		ATRX	NEK1
Description		ATRX chromatin remodeler	NIMA related kinase 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin Nuclear Body PML Body Chromosome, Subtelomeric Region	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding DNA Translocase Activity ATP Hydrolysis Activity Methylated Histone Binding Histone Binding Metal Ion Binding Chromo Shadow Domain Binding ATP-dependent Chromatin Remodeler Activity	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Meiotic Spindle Organization DNA Repair DNA Methylation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nuclear Cell Cycle DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Forebrain Development Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Post-embryonic Forelimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription By RNA Polymerase II Sertoli Cell Development Chromosome Organization Involved In Meiotic Cell Cycle Protein Localization To Chromosome, Telomeric Region Seminiferous Tubule Development Cellular Response To Hydroxyurea Regulation Of Histone H3-K9 Trimethylation Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Positive Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly
Pathways		Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs			Fostamatinib
Diseases
GWAS		Platelet count ( 32888494) Plateletcrit ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		29 interacting genes: ATN1 ATP1A3 AURKA BLM BRD9 CALM1 CCSER2 CEP126 CREBBP DAXX EZH2 H3C14 HDAC1 HDAC4 LUC7L2 MDM2 NEK1 NSD1 PTN PTPN4 RAD51 RASSF1 SUMO2 SVIL TP53 WRN ZBED1 ZMYND8 ZNF512B	27 interacting genes: ANXA10 ATRX CFAP410 CLCN3 CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 GTF2H4 H2BC21 HAND2 HIP1R KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD RTN4R SIRPA TAF9 TP53BP1 TSC2 YWHAH ZNF350
Entrez ID		546	4750
HPRD ID		02069	06847
Ensembl ID		ENSG00000085224	ENSG00000137601
Uniprot IDs		A4LAA3 B4DLW1 P46100	Q5JXL9 Q96PY6
PDB IDs		2JM1 2LBM 2LD1 3QL9 3QLA 3QLC 3QLN 4W5A 5GRQ 5Y18 5Y6O 6G0O	4APC 4B9D
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?