XRN1 and FADS1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		XRN1	FADS1
Description		5'-3' exoribonuclease 1	fatty acid desaturase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	C-5 Sterol Desaturase Activity Linoleoyl-CoA Desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Omega-6 Fatty Acid Desaturase Activity Acyl-CoA Delta5-desaturase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	Regulation Of Transcription, DNA-templated Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs			alpha-Linolenic acid Icosapent
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)	Alanine transaminase levels ( 29403010) Aortic valve stenosis ( 32186652) Asthma ( 31959851 34103634 32296059 31619474) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 24097068 25961943 20686565) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908 21102463) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Eosinophil counts ( 27863252) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679) Fatty acid desaturase activity (adipose tissue) ( 30453627) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) Glycerophospholipid levels ( 26068415) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 20864672 19060906 25961943 20686565) HDL cholesterol levels ( 28334899) Heart rate ( 23583979) Height ( 25429064) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29615537) Homeostasis model assessment of beta-cell function ( 20081858) Inflammatory bowel disease ( 23128233) Iron status biomarkers (total iron binding capacity) ( 33536631) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060910 30275531 25961943 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 23281178 23823483 23378610 22916037 20037589 19043545) Metabolite levels (lipid measures) ( 27005778) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494 27863252) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Oleic acid (18:1n-9) levels ( 28298293 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) PR interval ( 32439900) QT interval ( 30679814) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Rheumatoid arthritis ( 30423114 24390342) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748 23093944) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Sphingolipid levels ( 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29615537) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 29403010 33339817) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 20864672 19060906 25961943 20686565) Vaccenic acid (18:1n-7) levels ( 28298293) Vitamin C levels ( 33203707) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		67 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	3 interacting genes: EEF1G POLR2E XRN1
Entrez ID		54464	3992
HPRD ID		10470	06935
Ensembl ID		ENSG00000114127	ENSG00000149485
Uniprot IDs		Q8IZH2	A0A0A0MR51 O60427
PDB IDs
Enriched GO Terms of Interacting Partners?
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