FBXW5 and SASS6

Number of citations of the paper that reports this interaction (PubMedID 21725316)
71

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		FBXW5	SASS6
Description		F-box and WD repeat domain containing 5	SAS-6 centriolar assembly protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Centrosome Centriole Cytosol Centriolar Satellite Deuterosome
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Centriole Replication Centrosome Duplication
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Adiponectin levels ( 33562295)
Interacting Genes		36 interacting genes: ADAMTSL4 CYP1A1 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	3 interacting genes: FBXW5 FCHSD2 FZR1
Entrez ID		54461	163786
HPRD ID		10955	10907
Ensembl ID		ENSG00000159069	ENSG00000156876
Uniprot IDs		A0A024R8H7 Q969U6	B4DYM7 Q495U0 Q6UVJ0
PDB IDs			6Z4A
Enriched GO Terms of Interacting Partners?
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