POLR2E and GTF2F2

Number of citations of the paper that reports this interaction (PubMedID 11278533)
22

Data Source:
HPRD (in vivo, in vitro)

		POLR2E	GTF2F2
Description		RNA polymerase II, I and III subunit E	general transcription factor IIF subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton Transcription Preinitiation Complex
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity ATP Hydrolysis Activity
	Biological Process	Transcription By RNA Polymerase II	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA Duplex Unwinding
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)	Normal facial asymmetry (angle of surface orientation score) ( 30631343) Type 2 diabetes ( 25760438)
Interacting Genes		33 interacting genes: CHGB DCC FADS1 FKBP14 FOS GTF2B GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 NFIX PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 TUBGCP2 UBE2D4 URI1 ZSCAN1	34 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 MYC POLR2A POLR2E RBPMS RPL27A TAF5 TBP TCEA1 TRAM2 TSC22D1 TSPAN3 URI1 YEATS4 ZMYND19
Entrez ID		5434	2963
HPRD ID		15946	01804
Ensembl ID		ENSG00000099817	ENSG00000188342
Uniprot IDs		B4DJ89 E5KT65 P19388	A0A024RDU9 P13984
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59	1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L
Enriched GO Terms of Interacting Partners?
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