POLR2C and OTUD5

Number of citations of the paper that reports this interaction (PubMedID 30508113)
14

Data Source:
BioGRID (pull down)

		POLR2C	OTUD5
Description		RNA polymerase II subunit C	OTU deubiquitinase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol	Cytosol
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Thiol-dependent Deubiquitinase Lys63-specific Deubiquitinase Activity Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Transcription By RNA Polymerase II	Protein Deubiquitination Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Interacting Genes		29 interacting genes: ATF4 ATF7IP C11orf58 CCHCR1 EEF1A1 ERG28 ITCH LRIF1 MYOG NECAB2 NEDD4 NFKBIA NUDT21 OTUD5 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2K POLR2L SMARCC2 STC2 TAF15 UBC UBE2W	12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5
Entrez ID		5432	55593
HPRD ID		15945	06488
Ensembl ID		ENSG00000102978	ENSG00000068308
Uniprot IDs		P19387 Q6FGR6	A0A024QZ09 Q96G74
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?
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